PAX6 anticorps (N-Term)

N° du produit ABIN6295578

Cet anticorps anti-PAX6 est un anticorps Souris Monoclonal détectant PAX6 dans IF, FACS et IHC. Adapté pour Humain.

Aperçu rapide pour PAX6 anticorps (N-Term) (ABIN6295578)

Antigène: PAX6 (Paired Box 6 (PAX6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PAX6 est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC)

Détail du produit anti-PAX6 anticorps

Épitope: AA 1-300, N-Term

Fonction: Mouse anti-Human PAX-6 Antibody [Sodium Azide Free]

Specificité: Nuclear

Purification: A recombinant fragment (N-terminus, aa 1-300) was used as the immunogen for the PAX-6 antibody.

Immunogène: A recombinant fragment (N-terminus, aa 1-300) was used as the immunogen for the PAX-6 antibody.

Information d'application

Indications d'application: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur PAX6

Antigène: PAX6 (Paired Box 6 (PAX6))

Autre désignation: Paired box protein Pax-6

Sujet:

Target Description: Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.

Gene Symbol: PAX6///AN2

ID gène: 5080

UniProt: P26367

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis